作者
Zachary Kaminsky, Arturas Petronis, Sun-Chong Wang, Brian Levine, Omar Ghaffar, Darlene Floden, Anthony Feinstein
发表日期
2008/2
期刊
Twin Research and Human Genetics
卷号
11
期号
1
页码范围
1-11
出版商
Cambridge University Press
简介
DNA methylation differences between identical twins could account for phenotypic twin discordance of behavioral traits and diseases. High throughput epigenomic microarray profiling can be a strategy of choice for identification of epigenetic differences in phenotypically different monozygotic (MZ) twins. Epigenomic profiling of a pair of MZ twins with quantified measures of psychometric discordance identified several DNA methylation differences, some of which may have developmental and behavioral implications and are consistent with the contrasting psychometric profiles of the twins. In particular, differential methylation of CpG islands proximal to the homeobox DLX1 gene could modulate stress responses and risk taking behavior, and deserve further attention as a potential marker of aversion to danger. The epigenetic difference detected at DLX1 of ∼1.2 fold change was used to evaluate experimental design …
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Z Kaminsky, A Petronis, SC Wang, B Levine, O Ghaffar… - Twin Research and Human Genetics, 2008