作者
Michael Berk, DJ Stein, A Potgieter, CM Maud, C Els, ML Janet, E Viljoen
发表日期
2000/9/1
期刊
International clinical psychopharmacology
卷号
15
期号
5
页码范围
291-295
出版商
LWW
简介
Antidepressant induced sexual dysfunction is a common adverse event that is particularly evident with serotonergic antidepressants. There is a paucity of clinical trial evidence on the treatment of this problem. While there is some evidence of involvement of the serotonin (5-HT 2) receptor subtype in this phenomenon, other serotonergic receptor systems are not well studied. In this trial, 35 patients on maintenance therapy with a variety of serotonergic antidepressants, who reported antidepressant induced sexual dysfunction, were enrolled. Patients were given both granisetron 1 mg, and sumatriptan 100 mg, in a crossover design, to be used 1 h before intercourse. Sexual dysfunction was measured using the Feiger scale. There was a high dropout rate in the trial, reflecting both embarrassment with the pharmacological treatment of sexual dysfunction and difficulties with planning and timing the medication …
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M Berk, DJ Stein, A Potgieter, CM Maud, C Els… - International clinical psychopharmacology, 2000