作者
Ute Mons, Aysel Müezzinler, Carolin Gellert, Ben Schöttker, Christian C Abnet, Martin Bobak, Lisette de Groot, Neal D Freedman, Eugène Jansen, Frank Kee, Daan Kromhout, Kari Kuulasmaa, Tiina Laatikainen, Mark G O’Doherty, Bas Bueno-de-Mesquita, Philippos Orfanos, Annette Peters, Yvonne T van der Schouw, Tom Wilsgaard, Alicja Wolk, Antonia Trichopoulou, Paolo Boffetta, Hermann Brenner
发表日期
2015/4/20
期刊
bmj
卷号
350
出版商
British Medical Journal Publishing Group
简介
Objective To investigate the impact of smoking and smoking cessation on cardiovascular mortality, acute coronary events, and stroke events in people aged 60 and older, and to calculate and report risk advancement periods for cardiovascular mortality in addition to traditional epidemiological relative risk measures.
Design Individual participant meta-analysis using data from 25 cohorts participating in the CHANCES consortium. Data were harmonised, analysed separately employing Cox proportional hazard regression models, and combined by meta-analysis.
Results Overall, 503?905 participants aged 60 and older were included in this study, of whom 37?952 died from cardiovascular disease. Random effects meta-analysis of the association of smoking status with cardiovascular mortality yielded a summary hazard ratio of 2.07 (95% CI 1.82 to 2.36) for current smokers and 1.37 (1.25 to 1.49) for former smokers …
学术搜索中的文章
U Mons, A Müezzinler, C Gellert, B Schöttker, CC Abnet… - bmj, 2015