作者
Alison Avenell, Graeme S MacLennan, David J Jenkinson, Gladys C McPherson, Alison M McDonald, Puspa R Pant, Adrian M Grant, Marion K Campbell, Frazer H Anderson, Cyrus Cooper, Roger M Francis, William J Gillespie, C Michael Robinson, David J Torgerson, W Angus Wallace, RECORD Trial Group
发表日期
2012/2/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
97
期号
2
页码范围
614-622
出版商
Oxford University Press
简介
Context
Vitamin D or calcium supplementation may have effects on vascular disease and cancer.
Objective
Our objective was to investigate whether vitamin D or calcium supplementation affects mortality, vascular disease, and cancer in older people.
Design and Setting
The study included long-term follow-up of participants in a two by two factorial, randomized controlled trial from 21 orthopedic centers in the United Kingdom.
Participants
Participants were 5292 people (85% women) aged at least 70 yr with previous low-trauma fracture.
Interventions
Participants were randomly allocated to daily vitamin D3 (800 IU), calcium (1000 mg), both, or placebo for 24–62 months, with a follow-up of 3 yr after intervention.
Main Outcome Measures
All-cause mortality, vascular disease mortality, cancer mortality …
学术搜索中的文章
A Avenell, GS MacLennan, DJ Jenkinson… - The Journal of Clinical Endocrinology & Metabolism, 2012