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Almost 40% of the new drug candidates emerging from drug discovery programs have poor water solubility and this trend is not expected to change in the future [1]. Nowadays, a large portion of new molecules come from combinatorial chemistry that focuses on target-receptor geometry, target identification and lead candidate generation. However, candidates emerging from these screens invariably have high molecular mass and high Log P, which contribute to insolubility. Moreover, the high affinity and highly specific binding to molecular targets generally entails some degree of hydrophobic interactions, which lead to solubility