作者
Harold Brem, Marjana Tomic-Canic
发表日期
2007/5/1
来源
The Journal of clinical investigation
卷号
117
期号
5
页码范围
1219-1222
出版商
American Society for Clinical Investigation
简介
Diabetic foot ulcers (DFUs), a leading cause of amputations, affect 15% of people with diabetes. A series of multiple mechanisms, including decreased cell and growth factor response, lead to diminished peripheral blood flow and decreased local angiogenesis, all of which can contribute to lack of healing in persons with DFUs. In this issue of the JCI, Gallagher and colleagues demonstrate that in diabetic mice, hyperoxia enhances the mobilization of circulating endothelial progenitor cells (EPCs) from the bone marrow to the peripheral circulation (see the related article beginning on page 1249). Local injection of the chemokine stromal cell–derived factor–1α then recruits these EPCs to the cutaneous wound site, resulting in accelerated wound healing. Thus, Gallagher et al. have identified novel potential targets for therapeutic intervention in diabetic wound healing.
引用总数
学术搜索中的文章
H Brem, M Tomic-Canic - The Journal of clinical investigation, 2007