作者
Sabine A Eming, Paul Martin, Marjana Tomic-Canic
发表日期
2014/12/3
来源
Science translational medicine
卷号
6
期号
265
页码范围
265sr6-265sr6
出版商
American Association for the Advancement of Science
简介
The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body’s natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue …
学术搜索中的文章
SA Eming, P Martin, M Tomic-Canic - Science translational medicine, 2014