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Bone marrow erythroid progenitor cells (EPCs) are one specific target of infection by the Parvovirus B19 (B19V), a human pathogenic virus that can cause serious anemia in immunodeficient people. Moreover, characteristics of B19V include the ability to cross the placenta, infecting the fetus, and persist in several other tissues. The bone marrow hematopoietic niche, including the compartment of mesenchymal stromal cells (MSCs), is an important component in defining the tropism of this virus, thus a co-culture model based on the interaction between EPCs and MSCs would reveal new insight into the viral pathogenesis.