作者
Francesco Alviano, Valentina Fossati, Cosetta Marchionni, Mario Arpinati, Laura Bonsi, Michele Franchina, Giacomo Lanzoni, Silvia Cantoni, Claudia Cavallini, Francesca Bianchi, Pier Luigi Tazzari, Gianandrea Pasquinelli, Laura Foroni, Carlo Ventura, Alberto Grossi, Gian Paolo Bagnara
发表日期
2007/12
期刊
BMC developmental biology
卷号
7
页码范围
1-14
出版商
BioMed Central
简介
Background
Term Amniotic membrane (AM) is a very attractive source of Mesenchymal Stem Cells (MSCs) due to the fact that this fetal tissue is usually discarded without ethical conflicts, leading to high efficiency in MSC recovery with no intrusive procedures. Here we confirmed that term AM, as previously reported in the literature, is an abundant source of hMSCs; in particular we further investigated the AM differentiation potential by assessing whether these cells may also be committed to the angiogenic fate. In agreement with the recommendation of the International Society for Cellular Therapy, the mesenchymal cells herein investigated were named Amniotic Membrane-human Mesenchymal Stromal Cells (AM-hMSC).
Results
The recovery of hMSCs and their in vitro expansion potential were greater in amniotic membrane than in bone marrow stroma …
引用总数
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F Alviano, V Fossati, C Marchionni, M Arpinati, L Bonsi… - BMC developmental biology, 2007