作者
Thomas Wirth, Thibaut Goetsch, Jean-Christophe Corvol, Emmanuel Roze, Louise-Laure Mariani, Marie Vidailhet, David Grabli, Luc Mallet, Antoine Pelissolo, Olivier Rascol, Christine Brefel-Courbon, Fabienne Ory-Magne, Christophe Arbus, Samir Bekadar, Pierre Krystkowiak, Ana Marques, Michel Llorca, Paul Krack, Anna Castrioto, Valérie Fraix, David Maltete, Luc Defebvre, Alexandre Kreisler, Jean-Luc Houeto, Christine Tranchant, Nicolas Meyer, Mathieu Anheim
发表日期
2024/1/12
期刊
Journal of neurology
页码范围
1-11
出版商
Springer Berlin Heidelberg
简介
Background
The long-term prognosis of impulsive compulsive disorders (ICD) remains poorly studied in Parkinson’s disease (PD).
Objective
Evaluating the natural history of ICD and its impact on PD symptoms including cognition and treatment adjustments.
Materials and methods
We assessed PD patients at baseline (BL) with (BL-ICD+) or without (BL-ICD-) ICD despite dopamine agonist (DA) exposure of> 300 mg levodopa-equivalent daily dose for> 12 months at baseline and after more than two years of follow-up. ICD were assessed using the Ardouin’s Scale of Behaviors in PD (ASBPD), cognition using the Mattis scale, and PD symptoms using the UPDRS score. Treatment adjustments, DA withdrawal-associated symptoms, and ICDs social consequences were recorded.
Results
149 patients were included (78 cases and 71 controls), mean duration of follow-up was 4.4±1 years. At baseline, psychiatric disorders …
学术搜索中的文章
T Wirth, T Goetsch, JC Corvol, E Roze, LL Mariani… - Journal of neurology, 2024