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The human bone marrow (BM) is one of the most complex and critical tissues in the adult, functioning as the site for hematopoietic stem and progenitor cell (HSPC) maintenance, as well as blood and immune cell production in homeostasis, injury, and disease. As the development of human organs-on-a-chip (OoC) platforms has emerged over the past decade, there has been an increased relevance of using human BM models to study human-specific immune interactions in vitro. Here we report the development of a patient-specific bioengineered model of the BM, derived entirely from induced pluripotent stem cells (iPSCs) and its use in studies of radiation toxicity, cancer, and systemic injury responses.

The engineered model of human BM (eBM) is derived from iPSC-derived osteoblasts, mesenchymal stem/stromal cells, and endothelial cells within a decellularized bone scaffold. This model was developed to be …