作者
Mario Gaudino, Antonino Di Franco, John H Alexander, Faisal Bakaeen, Natalia Egorova, Paul Kurlansky, Andreas Boening, Joanna Chikwe, Michelle Demetres, Philip J Devereaux, Anno Diegeler, Arnaldo Dimagli, Marcus Flather, Irbaz Hameed, Andre Lamy, Jennifer S Lawton, Wilko Reents, N Bryce Robinson, Katia Audisio, Mohamed Rahouma, Patrick W Serruys, Hironori Hara, David P Taggart, Leonard N Girardi, Stephen E Fremes, Umberto Benedetto
发表日期
2022/1/1
来源
European heart journal
卷号
43
期号
1
页码范围
18-28
出版商
Oxford University Press
简介
Aims
Data suggest that women have worse outcomes than men after coronary artery bypass grafting (CABG), but results have been inconsistent across studies. Due to the large differences in baseline characteristics between sexes, suboptimal risk adjustment due to low-quality data may be the reason for the observed differences. To overcome this limitation, we undertook a systematic review and pooled analysis of high-quality individual patient data from large CABG trials to compare the adjusted outcomes of women and men.
Methods and results
The primary outcome was a composite of all-cause mortality, myocardial infarction (MI), stroke, and repeat revascularization (major adverse cardiac and cerebrovascular events, MACCE). The secondary outcome was all-cause mortality. Multivariable mixed-effect Cox regression was used. Four trials involving 13 193 patients (10 …
学术搜索中的文章
M Gaudino, A Di Franco, JH Alexander, F Bakaeen… - European heart journal, 2022