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Background:

HIV-infected African-Americans are at increased risk of end-stage renal disease requiring renal replacement therapy (RRT).

Objectives:

To compare the incidence of RRT in HIV-infected and HIV-seronegative African-Americans and describe temporal trends in RRT and chronic kidney disease (CKD) in HIV infection.

Design:

Cohort study in Baltimore including 4509 HIV-infected and 1746 HIV-seronegative African-Americans.

Methods:

Incident RRT was defined by matching participant identifiers with the US Renal Data System; CKD was defined as an estimated glomerular filtration rate< 60 ml/min per 1.73 m 2 for≥ 3 months. Standardized incidence ratios (SIR) and 95% confidence intervals (CI) were calculated by indirect adjustment. Risk factors for RRT were assessed by person-time methods and Poisson regression.

Results:

RRT was initiated in 24 HIV-seronegative subjects over 13 415 person-years of …