作者
Theresa Schwaiger, Cindy van den Brandt, Brit Fitzner, Sarah Zaatreh, Franziska Kraatz, Annegret Dummer, Horst Nizze, Matthias Evert, Barbara M Bröker, Monika C Brunner-Weinzierl, Thomas Wartmann, Tareq Salem, Markus M Lerch, Robert Jaster, Julia Mayerle
发表日期
2014/3/1
期刊
Gut
卷号
63
期号
3
页码范围
494-505
出版商
BMJ Publishing Group
简介
Background
Autoimmune pancreatitis (AIP) in humans invariably responds to steroid treatment, but little is known about the underlying pathogenesis and the benefits of alternative treatments.
Objective
To study the pathogenesis, and the efficacy of alternative immunosuppressant agents in the MRL/Mp mouse model of AIP.
Design
MRL/Mp mice were pretreated for 4 weeks with polyinosinic:polycytidylic acid to induce AIP. Pancreatic sections of mice genetically deleted for CTLA-4 were analysed. Blockage of CTLA-4 was achieved by intraperitoneal antibody treatment with 2 μg/g anti-mouse-CD152. Subsequent therapeutic studies were performed for a period of 4 weeks using cyclosporine A (40 μg/g), rapamycin (1 μg/g) or azathioprine (15 μg/g).
Results
Blockage of CTLA-4 in MRL/Mp mice suppressed regulatory T cell (Treg) function and raised the effector T cell (Teff) response with subsequent …
学术搜索中的文章
T Schwaiger, C van den Brandt, B Fitzner, S Zaatreh… - Gut, 2014