作者
Dominick E Shaw, Ana R Sousa, Stephen J Fowler, Louise J Fleming, Graham Roberts, Julie Corfield, Ioannis Pandis, Aruna T Bansal, Elisabeth H Bel, Charles Auffray, Chris H Compton, Hans Bisgaard, Enrica Bucchioni, Massimo Caruso, Pascal Chanez, Barbro Dahlén, Sven-Erik Dahlen, Kerry Dyson, Urs Frey, Thomas Geiser, Maria Gerhardsson De Verdier, David Gibeon, Yi-ke Guo, Simone Hashimoto, Gunilla Hedlin, Elizabeth Jeyasingham, Pieter-Paul W Hekking, Tim Higenbottam, Ildikó Horváth, Alan J Knox, Norbert Krug, Veit J Erpenbeck, Lars X Larsson, Nikos Lazarinis, John G Matthews, Roelinde Middelveld, Paolo Montuschi, Jacek Musial, David Myles, Laurie Pahus, Thomas Sandström, Wolfgang Seibold, Florian Singer, Karin Strandberg, Jorgen Vestbo, Nadja Vissing, Christophe Von Garnier, Ian M Adcock, Scott Wagers, Anthony Rowe, Peter Howarth, Ariane H Wagener, Ratko Djukanovic, Peter J Sterk, Kian Fan Chung
发表日期
2015/11/1
期刊
European Respiratory Journal
卷号
46
期号
5
页码范围
1308-1321
出版商
European Respiratory Society
简介
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.
This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.
Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function …
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DE Shaw, AR Sousa, SJ Fowler, LJ Fleming, G Roberts… - European Respiratory Journal, 2015