作者
Gulsim K Kulsharova, Matthew B Lee, Felice Cheng, Munima Haque, Hyungsoo Choi, Kyekyoon Kim, William D O'Brien, G Logan Liu
发表日期
2013/8/15
期刊
IEEE transactions on nanobioscience
卷号
12
期号
4
页码范围
304-310
出版商
IEEE
简介
Gelatin nanoparticles coated with Cathepsin D-specific peptides were developed as a vehicle for the targeted delivery of the cancer drug doxorubicin (DOX) to treat breast malignancy. Cathepsin D, a breast cancer cell secretion enzyme, triggered the release of DOX by digesting the protective peptide-coating layer of nanoparticles. Fabricated nanoparticles were successfully detected with ultrasound imaging in both in vitro conditions and in vivo mouse cancer models. Cell viability experiments were conducted to determine the efficacy of biomarker activation specific to breast cancer cell lines. These experimental results were compared with the outcome of a viability experiment conducted on noncancerous cells. Viability decreased in human MCF7 mammary adenocarcinoma and mouse 4T1 mammary carcinoma cells, while that of noncancerous 3T3 fibroblast cells remained unaffected. Next, a real-time video of …
学术搜索中的文章
GK Kulsharova, MB Lee, F Cheng, M Haque, H Choi… - IEEE transactions on nanobioscience, 2013