作者
Ben Schöttker, Rolf Jorde, Anne Peasey, Barbara Thorand, Eugène HJM Jansen, Lisette De Groot, Martinette Streppel, Julian Gardiner, José Manuèl Ordóñez-Mena, Laura Perna, Tom Wilsgaard, Wolfgang Rathmann, Edith Feskens, Ellen Kampman, Galatios Siganos, Inger Njølstad, Ellisiv Bøgeberg Mathiesen, Růžena Kubínová, Andrzej Pająk, Roman Topor-Madry, Abdonas Tamosiunas, Maria Hughes, Frank Kee, Martin Bobak, Antonia Trichopoulou, Paolo Boffetta, Hermann Brenner
发表日期
2014/6/17
期刊
Bmj
卷号
348
出版商
British Medical Journal Publishing Group
简介
Objective To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences.
Design Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US.
Setting General population.
Participants 26 018 men and women aged 50-79 years
Main outcome measures All-cause, cardiovascular, and cancer mortality.
Results 25(OH)D concentrations varied strongly by season (higher in summer), country (higher in US and northern Europe) and sex (higher in men), but no consistent trend with age was observed. During follow-up, 6695 study participants died, among whom 2624 died of cardiovascular diseases and 2227 died of cancer. For each cohort and analysis, 25(OH)D quintiles were defined with cohort and subgroup specific …
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