作者
Ben Schöttker, Hermann Brenner, Eugène HJM Jansen, Julian Gardiner, Anne Peasey, Růžena Kubínová, Andrzej Pająk, Roman Topor-Madry, Abdonas Tamosiunas, Kai-Uwe Saum, Bernd Holleczek, Hynek Pikhart, Martin Bobak
发表日期
2015/12
期刊
BMC medicine
卷号
13
页码范围
1-15
出版商
BioMed Central
简介
Background
The free radical/oxidative stress theory of ageing has received considerable attention, but the evidence on the association of oxidative stress markers with mortality is sparse.
Methods
We measured derivatives of reactive oxygen metabolite (D-ROM) levels as a proxy for the reactive oxygen species concentration and total thiol levels (TTL) as a proxy for the redox control status in 10,622 men and women (age range, 45–85 years), from population-based cohorts from Germany, Poland, Czech Republic, and Lithuania, of whom 1,702 died during follow-up.
Results
Both oxidative stress markers were significantly associated with all-cause mortality independently from established risk factors (including inflammation) and from each other in all cohorts. Regarding cause-specific mortality, compared to low D-ROM …
学术搜索中的文章
B Schöttker, H Brenner, EHJM Jansen, J Gardiner… - BMC medicine, 2015