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Figure 1. RNAi, transposon silencing, and cosuppression are related but distinct mechanisms. Two independent forward screens were performed to identify rde and mut genes. The results partially overlap, suggesting that RNAi and transposon silencing are related processes. Specific rde and mut genes have also been identified in those screens, showing that these mechanisms are nevertheless distinct. Interestingly, the rde/mut genes are also required for cosuppression.