作者
Venice Servellita, Abdullah M Syed, Mary Kate Morris, Noah Brazer, Prachi Saldhi, Miguel Garcia-Knight, Bharath Sreekumar, Mir M Khalid, Alison Ciling, Pei-Yi Chen, G Renuka Kumar, Amelia S Gliwa, Jenny Nguyen, Alicia Sotomayor-Gonzalez, Yueyuan Zhang, Edwin Frias, John Prostko, John Hackett, Raul Andino, Debra A Wadford, Carl Hanson, Jennifer Doudna, Melanie Ott, Charles Y Chiu
发表日期
2022/4/28
期刊
Cell
卷号
185
期号
9
页码范围
1539-1548. e5
出版商
Elsevier
简介
Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated individuals. Following Delta breakthrough infection, titers against WT rose 57-fold and 3.1-fold compared with uninfected boosted and unboosted individuals, respectively, versus only a 5.8-fold increase and 3.1-fold decrease for Omicron breakthrough infection. Among immunocompetent, unboosted patients, Delta breakthrough infections induced 10.8-fold higher titers against WT compared with Omicron (p = 0.037). Decreased antibody responses in Omicron breakthrough infections relative to Delta were potentially related to a higher proportion of asymptomatic or mild breakthrough infections (55.0% versus 28.6%, respectively), which exhibited 12.3-fold lower titers against WT compared with moderate to severe infections (p = 0.020 …
学术搜索中的文章
V Servellita, AM Syed, MK Morris, N Brazer, P Saldhi… - Cell, 2022