作者
Roger Stupp, Sophie Taillibert, Andrew Kanner, William Read, David M Steinberg, Benoit Lhermitte, Steven Toms, Ahmed Idbaih, Manmeet S Ahluwalia, Karen Fink, Francesco Di Meco, Frank Lieberman, Jay-Jiguang Zhu, Giuseppe Stragliotto, David D Tran, Steven Brem, Andreas F Hottinger, Eilon D Kirson, Gitit Lavy-Shahaf, Uri Weinberg, Chae-Yong Kim, Sun-Ha Paek, Garth Nicholas, Jordi Bruna, Hal Hirte, Michael Weller, Yoram Palti, Monika E Hegi, Zvi Ram
发表日期
2017/12/19
期刊
Jama
卷号
318
期号
23
页码范围
2306-2316
出版商
American Medical Association
简介
Importance
Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity alternating electric fields to the tumor.
Objective
To investigate whether TTFields improves progression-free and overall survival of patients with glioblastoma, a fatal disease that commonly recurs at the initial tumor site or in the central nervous system.
Design, Setting, and Participants
In this randomized, open-label trial, 695 patients with glioblastoma whose tumor was resected or biopsied and had completed concomitant radiochemotherapy (median time from diagnosis to randomization, 3.8 months) were enrolled at 83 centers (July 2009-2014) and followed up through December 2016. A preliminary report from this trial was published in 2015; this report describes the final analysis.
Interventions
Patients were randomized 2:1 to TTFields plus …
学术搜索中的文章
R Stupp, S Taillibert, A Kanner, W Read, DM Steinberg… - Jama, 2017