作者
Manmeet Ahluwalia, Gene H Barnett, Di Deng, Stephen B Tatter, Adrian W Laxton, Alireza M Mohammadi, Eric Leuthardt, Roukoz Chamoun, Kevin Judy, Anthony Asher, Marco Essig, Jorg Dietrich, Veronica L Chiang
发表日期
2018/5/4
期刊
Journal of neurosurgery
卷号
130
期号
3
页码范围
804-811
出版商
American Association of Neurological Surgeons
简介
OBJECTIVE
Laser Ablation After Stereotactic Radiosurgery (LAASR) is a multicenter prospective study of laser interstitial thermal (LITT) ablation in patients with radiographic progression after stereotactic radiosurgery for brain metastases.
METHODS
Patients with a Karnofsky Performance Scale (KPS) score ≥ 60, an age > 18 years, and surgical eligibility were included in this study. The primary outcome was local progression-free survival (PFS) assessed using the Response Assessment in Neuro-Oncology Brain Metastases (RANO-BM) criteria. Secondary outcomes were overall survival (OS), procedure safety, neurocognitive function, and quality of life.
RESULTS
Forty-two patients—19 with biopsy-proven radiation necrosis, 20 with recurrent tumor, and 3 with no diagnosis—were enrolled. The median age was 60 years, 64% of the subjects …
学术搜索中的文章
M Ahluwalia, GH Barnett, D Deng, SB Tatter… - Journal of neurosurgery, 2018