作者
DA Reardon, A Omuro, AA Brandes, J Rieger, A Wick, J Sepulveda, S Phuphanich, P De Souza, MS Ahluwalia, M Lim, G Vlahovic, J Sampson
发表日期
2017/4
期刊
Neuro-oncology
卷号
19
期号
suppl_3
页码范围
iii21-iii21
出版商
Oxford University Press
简介
Background: Oligodendrogliomas (OGs) are diffuse gliomas defined by IDH mutation and 1p/19q codeletion, in which response to treatment and survival are dictated not by histology, but by molecular subtypes. Methods: The US NCDB was queried for OG patients newly-diagnosed from 2004–2014. Patient and tumor factors were compared by Chi2 or t test. Overall survival (OS) was assessed by Cox proportional hazards and Kaplan-Meier methods, stratified by histology, grade, and codeletion status, and risk adjusted for age, sex, race, Charlson’s comorbidity index, insurance, facility location, chemoradiotherapy, and tumor location, laterality, and size. Results: 14,948 patients with gliomas with OG histology remained after exclusion, 67% (n=10,075) were WHO gr2, 33% were WHO gr3 (i.e. anaplastic), and 36% displayed mixed oligoastrocytoma histology. Complete 1p/19q data were available in 20% (n …
引用总数
201720182019202020212022202320241255816859262014