作者
Andrew E Sloan, Manmeet S Ahluwalia, Jose Valerio-Pascua, Sunil Manjila, Mark G Torchia, Stephen E Jones, Jeffrey L Sunshine, Michael Phillips, Mark A Griswold, Mark Clampitt, Cathy Brewer, Jennifer Jochum, Mary V McGraw, Dawn Diorio, Gail Ditz, Gene H Barnett
发表日期
2013/6/1
期刊
Journal of neurosurgery
卷号
118
期号
6
页码范围
1202-1219
出版商
American Association of Neurological Surgeons
简介
Object
Laser interstitial thermal therapy has been used as an ablative treatment for glioma; however, its development was limited due to technical issues. The NeuroBlate System incorporates several technological advances to overcome these drawbacks. The authors report a Phase I, thermal dose–escalation trial assessing the safety and efficacy of NeuroBlate in recurrent glioblastoma multiforme (rGBM).
Methods
Adults with suspected supratentorial rGBM of 15- to 40-mm dimension and a Karnofsky Performance Status score of ≥ 60 were eligible. After confirmatory biopsy, treatment was delivered using a rigid, gas-cooled, side-firing laser probe. Treatment was monitored using real-time MRI thermometry, and proprietary software providing predictive thermal damage feedback was used by the surgeon, along with control of probe rotation and depth, to tailor tissue coagulation …
学术搜索中的文章
AE Sloan, MS Ahluwalia, J Valerio-Pascua, S Manjila… - Journal of neurosurgery, 2013