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Opportunistic fungal infections are rising at alarming rates in immunocompromised individuals. There is no licensed fungal vaccine available, nor there a clear understanding of the protective host responses. In a mouse model of fungal vaccine-immunity in CD4+ T-cell lymphopenia, we have previously shown that vaccine-induced IL-17A producing CD8+ T (Tc17) cells are necessary for controlling lethal fungal pneumonia. However, we found a significant number of Tc17 cells that co-expressed GM-CSF (> 50%), but their role has been implicated as ‘pathogenic’in autoimmune disorders. In this study, using state-of-the-art approaches, we found that GM-CSF+ Tc17 cells are essential for vaccine-immunity against lethal fungal pneumonia without precipitating an adverse immunopathology. Induction of GM-CSF+ Tc17 cells, following vaccination, required signaling from cytokines, IL-1 and IL-23, that promoted …