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Schizophrenia is a highly heritable disorder characterized by disruptions on the molecular, cellular, and neural circuit level that lead to the behaviors and cognitive impairments associated with the illness. This chapter evaluates how combining neuroimaging methods with genetic approaches such as studying single genes and polygenic risk scores, to genome-wide association study (GWAS) variants and gene expression networks, can provide valuable insight into both biomarkers of schizophrenia and underlying neural mechanisms. Discussions begin with the evolving focus on smaller studies and a few genetic variants to larger scale multi-variant initiatives, and the benefits and challenges of both. The implications of recent findings are explored from bottom-up studies investigating brain abnormalities associated with candidate and GWAS identified variants individually, as well as the utility of examining …