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Background

Functional connectivity differences in the cortico-striatal-thalamic-cortical (CSTC) circuit, as well as altered subcortical region volumes have been observed in schizophrenia. In this study, magnetic resonance imaging was used in a large child and youth sample aged 11-21 years (n= 1134) to examine this circuit in children with psychosis spectrum (PS) symptoms (n= 312).

Methods

Structural subregions of the thalamus and striatum were identified using the segmentation tool MAGeT Brain. Functional subregions were segmented based on resting-state functional connectivity with brain networks. Average BOLD signal time series from functional subregions were correlated vertex-wide with cortical surfaces. FSL’s PALM was used to examine main effects and interactions between PS groups and sex on functional connectivity with TFCE. Age, in scanner motion, and WRAT score were included as covariates …