作者
Grace Jacobs, Aristotle Voineskos, Natalie Forde, Erin Dickie, Meng-Chuan Lai, Peter Szatmari, Russell Schachar, Jennifer Crosbie, Paul Arnold, Margot J Taylor, Anna Goldenberg, Lauren Erdman, Jason P Lerch, Evdokia Anagnostou, Stephanie Ameis
发表日期
2019/5/15
期刊
Biological Psychiatry
卷号
85
期号
10
页码范围
S123-S124
出版商
Elsevier
简介
Background
Neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD) are each highly heterogeneous conditions that feature significant overlap in behaviours, genetic risk factors, cognitive and brain alterations. We used Similarity Network Fusion (SNF), a multi-data integrative clustering tool, to identify novel groups across NDDs featuring more homogeneous brain-behaviour profiles than those associated with categorical DSM diagnoses.
Methods
Measures from T1-weighted (cortical thickness, subcortical volume) and diffusion-weighted (fractional anisotropy) magnetic resonance imaging, and behavioural scores, were obtained for 182 children, aged 6-16 years with ASD (n= 91), ADHD (n= 52) or OCD (n= 39) from the Province of Ontario Neurodevelopmental Disorders (POND) Network. Data …
学术搜索中的文章
G Jacobs, A Voineskos, N Forde, E Dickie, MC Lai… - Biological Psychiatry, 2019