作者
Sylvain P Chantepie, Sylvain Garciaz, Emmanuelle Tchernonog, Frederic Peyrade, Marie‐Virginie Larcher, Momar Diouf, Luc‐Mathieu Fornecker, Roch Houot, Thomas Gastinne, Carole Soussain, Sandra Malak, Richard Lemal, Caroline Delette, Ahmad Ibrahim, Anne‐Claire Gac, Emilie Reboursière, Jean‐Pierre Vilque, Mohamed‐Amine Bekadja, Rene‐Olivier Casasnovas, Remy Gressin, Stéphanie Guidez, Diane Coso, Charles Herbaux, Ibrahim Yakoub‐Agha, Krimo Bouabdallah, Eric Durot, Gandhi Damaj
发表日期
2018/6
期刊
American journal of hematology
卷号
93
期号
6
页码范围
729-735
简介
Carmustine shortage has led to an increase use of alternative conditioning regimens prior to autologous stem cell transplantation for the treatment of lymphoma, including Bendamustine‐based (BeEAM). The aim of this study was to evaluate the safety of the BeEAM regimen in a large cohort of patients. A total of 474 patients with a median age of 56 years were analyzed. The majority of patients had diffuse large B‐cell lymphoma (43.5%). Bendamustine was administered at a median dose of 197 mg/m2/day (50‐250) on days‐7 and −6. The observed grade 1‐4 toxicities included mucositis (83.5%), gastroenteritis (53%), skin toxicity (34%), colitis (29%), liver toxicity (19%), pneumonitis (5%), and cardiac rhythm disorders (4%). Nonrelapse mortality (NRM) was reported in 3.3% of patients. Acute renal failure (ARF) was reported in 132 cases (27.9%) (G ≥2; 12.3%). Organ toxicities and death were more frequent in …
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SP Chantepie, S Garciaz, E Tchernonog, F Peyrade… - American journal of hematology, 2018