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Figure 1. CD33 expression and impact on outcome according to treatment arm.(A) The concordance between the percentage of CD331 blast cells and the CD33 MFI ratio. To properly calculate the CD33 MFI ratio, at least 500 lymphocytes and blast cells had to be acquired and fewer than 20% of acquired lymphocyte events had to fall in channel 0 at the electronic digitizing step of fluorescence light intensities for CD33 labeling. The 2 boxes separate low/int-CD331 and high-CD331 patients on the basis of a threshold of 70% for CD331 blasts and of 15 for CD33 MFI ratio.(B) In low/int-CD331 patients (, 70%), EFS was estimated at 23% vs 26% at 2 years in the GO and control arms, respectively (HR, 0.89; 95% confidence interval [CI], 0.52-1.50; P 5. 66). Conversely, in high-CD331 patients ($70%), 2-year EFS was 49% vs 17% in the GO and control arms, respectively (HR, 0.56; 95% CI, 0.37-0.85; P 5. 0051). Tests for …