作者
Timea Kurdiova, Miroslav Balaz, Marek Vician, Denisa Maderova, Miroslav Vlcek, Ladislav Valkovic, Miroslav Srbecky, Richard Imrich, Olga Kyselovicova, Vitazoslav Belan, Ivan Jelok, Christian Wolfrum, Iwar Klimes, Martin Krssak, Erika Zemkova, Daniela Gasperikova, Jozef Ukropec, Barbara Ukropcova
发表日期
2014/3/1
期刊
The Journal of physiology
卷号
592
期号
5
页码范围
1091-1107
简介
Key points
- Considerable controversy exists regarding the role of irisin, a putative exercise‐induced myokine, in human metabolism.
- We therefore studied irisin and its precursor Fndc5 in obesity, type 2 diabetes and exercise.
- Complex clinical studies combined with cell culture work revealed that Fndc5/irisin was decreased in type 2 diabetes in vivo, but not in muscle cells in vitro, indicating that diabetes‐related factor(s) regulate Fndc5/irisin in vivo.
- Several attributes of type 2 diabetes, such as hyperglycaemia, triglyceridaemia, visceral adiposity and extramyocellular lipid deposition were negatively associated with adipose tissue Fndc5 mRNA and circulating irisin. Moreover, mimicking diabetic status in vitro by treating muscle cells with palmitate and glucose lowered Fndc5 mRNA.
- Neither exercise training nor an acute exercise bout modulated circulating irisin or muscle Fndc5 expression. However, the associations …
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