作者
Mariana Mirabel, Romain Sonneville, David Hajage, Emmanuel Novy, Florence Tubach, Philippe Vignon, Pierre Perez, Sylvain Lavoué, Achille Kouatchet, Olivier Pajot, Armand Mekontso-Dessap, Jean-Marie Tonnelier, Pierre-Edouard Bollaert, Jean-Pierre Frat, Jean-Christophe Navellou, Herve Hyvernat, Ali Ait Hssain, Jean-François Timsit, Bruno Megarbane, Michel Wolff, Jean-Louis Trouillet, ENDOREA Study Group
发表日期
2014/5/7
期刊
European heart journal
卷号
35
期号
18
页码范围
1195-1204
出版商
Oxford University Press
简介
Aims
To assess long-term outcomes and the management of critical left-sided infective endocarditis (IE) and evaluate the impact of surgery.
Methods and results
Among the 198 patients included prospectively for IE across 33 adult intensive care units (ICU) in France from 1 April 2007 to 1 October 2008, 137 (69%) were dead at a median follow-up time of 59.5 months. Characteristics significantly associated with mortality were: Sepsis-related Organ-Failure Assessment (SOFA) score at ICU admission [Hazard ratio (HR), 95% Confidence Interval (CI) of 1.43 (0.79–2.59) for SOFA 5–9; 2.01 (1.05–3.85) for SOFA 10–14; 3.53 (1.75–7.11) for SOFA 15–20; reference category SOFA 0–4; P = 0.003]; prosthetic mechanical valve IE [HR 2.01; 95% CI 1.09–3.69, P = 0.025]; vegetation size ≥15 mm [HR 1.64; 95% CI 1.03–2.63, P = 0.038]; and cardiac surgery [HR (95%CI), 0.33 (0.16–0.67 …
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M Mirabel, R Sonneville, D Hajage, E Novy, F Tubach… - European heart journal, 2014