作者
Arnaud W Thille, Grégoire Muller, Arnaud Gacouin, Rémi Coudroy, Maxens Decavèle, Romain Sonneville, François Beloncle, Christophe Girault, Laurence Dangers, Alexandre Lautrette, Séverin Cabasson, Anahita Rouzé, Emmanuel Vivier, Anthony Le Meur, Jean-Damien Ricard, Keyvan Razazi, Guillaume Barberet, Christine Lebert, Stephan Ehrmann, Caroline Sabatier, Jeremy Bourenne, Gael Pradel, Pierre Bailly, Nicolas Terzi, Jean Dellamonica, Guillaume Lacave, Pierre-Éric Danin, Hodanou Nanadoumgar, Aude Gibelin, Lassane Zanre, Nicolas Deye, Alexandre Demoule, Adel Maamar, Mai-Anh Nay, René Robert, Stéphanie Ragot, Jean-Pierre Frat
发表日期
2019/10/15
期刊
Jama
卷号
322
期号
15
页码范围
1465-1475
出版商
American Medical Association
简介
Importance
High-flow nasal oxygen may prevent postextubation respiratory failure in the intensive care unit (ICU). The combination of high-flow nasal oxygen with noninvasive ventilation (NIV) may be an optimal strategy of ventilation to avoid reintubation.
Objective
To determine whether high-flow nasal oxygen with prophylactic NIV applied immediately after extubation could reduce the rate of reintubation, compared with high-flow nasal oxygen alone, in patients at high risk of extubation failure in the ICU.
Design, Setting, and Participants
Multicenter randomized clinical trial conducted from April 2017 to January 2018 among 641 patients at high risk of extubation failure (ie, older than 65 years or with an underlying cardiac or respiratory disease) at 30 ICUs in France; follow-up was until April 2018.
Interventions
Patients were randomly assigned to high-flow nasal oxygen alone (n = 306) or high-flow nasal oxygen …
学术搜索中的文章
AW Thille, G Muller, A Gacouin, R Coudroy… - Jama, 2019