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Females with cystic fibrosis (CF) have lower pregnancy rates than the general population, and up to one-third experience infertility and may require assisted reproductive technologies to conceive [1]. Cervical mucus, which thins mid-cycle prior to ovulation to facilitate fertilization, may modulate fertility in CF. The CFTR protein is found in the cervix and its expression is regulated by sex hormones; normal protein function allows for appropriate bicarbonate secretion and mucus release [2]. Thus, it is biologically plausible that CF-related defects in the CFTR protein could impair cervical mucus quality and, by extension, fertility. If this is the case, highly effective modulator therapy (HEMT) may reverse these effects. One small study and case reports have described thickened cervical mucus in small numbers of females with CF, but these predated the advent of HEMT [3, 4]. In this study, we compared cervical mucus quality …