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Introduction: About 7% of world populations suffer from diabetes disease and its widespread complications. There are several studies about the beneficial effects of aerobic and resistance exercises on blood glucose and lipids levels, insulin sensitivity in type 2 diabetic patients. However, there is no study to investigate the effects of eccentric exercise in these patients. This study was designed to compare the effect of eccentric and concentric exercises on some of the blood biochemical parameters in type 2 of diabetic patients. Materials and Methods: 28 type 2 diabetic patients were assigned randomly in one of the two experimental eccentric and concentric groups. Before and after control and also after intervention, blood sugers, HbA1c, lipids and body mass index were measured. Results: The results showed that eccentric and concentric exercises result in a significant decrease in blood sugar, HbA1c, and …