作者
Yingmei Zhang, Zhuo Zhang, Jinmei Li, Limin Li, Xueying Han, Lina Han, Longhu Hu, Shuye Wang, Yanhong Zhao, Xiaoxia Li, Ying Zhang, Shengjin Fan, Chengfang Lv, Yinghua Li, Yanhua Su, Hui Zhao, Xin Zhang, Jin Zhou
发表日期
2013/1/1
期刊
Cancer
卷号
119
期号
1
页码范围
115-125
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
The prognosis of acute promyelocytic leukemia (APL) in the elderly is poorer than that of younger patients after treatment with all‐trans retinoic acid plus chemotherapy, which is the current standard therapy for APL. A significantly higher mortality during consolidation therapy was found, which is mainly due to deaths from sepsis following chemotherapy‐induced myelosuppression.
METHODS
A total of 33 patients aged 60 years or older with de novo APL were treated with single‐agent arsenic trioxide (ATO) for remission induction and postremission therapy. The postremission therapy continued for up to 4 years.
RESULTS
Twenty‐nine patients (87.9%) achieved a hematologic complete remission, and the most common adverse event during remission induction was leukocytosis (63.6%). Definite differentiation syndrome was observed in 5 patients. Nonhematologic adverse events were all …
学术搜索中的文章
Y Zhang, Z Zhang, J Li, L Li, X Han, L Han, L Hu… - Cancer, 2013