作者
Hua Zhang, Han Han, Tianhui He, Kristen E Labbe, Adrian V Hernandez, Haiquan Chen, Vamsidhar Velcheti, Justin Stebbing, Kwok-Kin Wong
发表日期
2021/4/1
来源
JNCI: Journal of the National Cancer Institute
卷号
113
期号
4
页码范围
371-380
出版商
Oxford University Press
简介
Background
Previous studies have indicated coronavirus disease 2019 (COVID-19) patients with cancer have a high fatality rate.
Methods
We conducted a systematic review of studies that reported fatalities in COVID-19 patients with cancer. A comprehensive meta-analysis that assessed the overall case fatality rate and associated risk factors was performed. Using individual patient data, univariate and multivariable logistic regression analyses were used to estimate odds ratios (OR) for each variable with outcomes.
Results
We included 15 studies with 3019 patients, of which 1628 were men; 41.0% were from the United Kingdom and Europe, followed by the United States and Canada (35.7%), and Asia (China, 23.3%). The overall case fatality rate of COVID-19 patients with cancer measured 22.4% (95% confidence interval [CI] = 17.3% to 28.0 …
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H Zhang, H Han, T He, KE Labbe, AV Hernandez… - JNCI: Journal of the National Cancer Institute, 2021