作者
Penny F Whiting, Robert F Wolff, Sohan Deshpande, Marcello Di Nisio, Steven Duffy, Adrian V Hernandez, J Christiaan Keurentjes, Shona Lang, Kate Misso, Steve Ryder, Simone Schmidlkofer, Marie Westwood, Jos Kleijnen
发表日期
2015/6/23
来源
Jama
卷号
313
期号
24
页码范围
2456-2473
出版商
American Medical Association
简介
Importance
Cannabis and cannabinoid drugs are widely used to treat disease or alleviate symptoms, but their efficacy for specific indications is not clear.
Objective
To conduct a systematic review of the benefits and adverse events (AEs) of cannabinoids.
Data Sources
Twenty-eight databases from inception to April 2015.
Study Selection
Randomized clinical trials of cannabinoids for the following indications: nausea and vomiting due to chemotherapy, appetite stimulation in HIV/AIDS, chronic pain, spasticity due to multiple sclerosis or paraplegia, depression, anxiety disorder, sleep disorder, psychosis, glaucoma, or Tourette syndrome.
Data Extraction and Synthesis
Study quality was assessed using the Cochrane risk of bias tool. All review stages were conducted independently by 2 reviewers. Where possible, data were pooled using random-effects meta-analysis.
Main Outcomes and Measures
Patient-relevant/disease …
学术搜索中的文章
PF Whiting, RF Wolff, S Deshpande, M Di Nisio, S Duffy… - Jama, 2015