作者
Eugenio Paci, Donella Puliti, Andrea Lopes Pegna, Laura Carrozzi, Giulia Picozzi, Fabio Falaschi, Francesco Pistelli, Ferruccio Aquilini, Cristina Ocello, Marco Zappa, Francesca M Carozzi, Mario Mascalchi
发表日期
2017/9/1
期刊
Thorax
卷号
72
期号
9
页码范围
825-831
出版商
BMJ Publishing Group Ltd
简介
Background
ITALUNG is contributing to the European evaluation of low-dose CT (LDCT) screening for lung cancer (LC).
Methods
Eligible subjects aged 55–69 years, smokers or ex-smokers (at least 20 pack-years in the last 10 years), were randomised to receive an annual invitation for LDCT screening for 4 years (active group) or to usual care (control group). All participants were followed up for vital status and cause of death (at the end of 2014) and LC incidence (at the end of 2013). Pathological and clinical information was collected from the Tuscan Cancer Registry data.
Results
1613 subjects were randomly assigned to the active group and 1593 to the control group. At the end of the follow-up period 67 LC cases were diagnosed in the active group and 71 in the control group (rate ratio (RR)=0.93; 95% CI 0.67 to 1.30). A greater proportion of stage I LC was observed in the active group (36% vs 11%, p<0.001 …
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E Paci, D Puliti, AL Pegna, L Carrozzi, G Picozzi… - Thorax, 2017