作者
Nathalie Reix, Charlotte Malina, Marie-Pierre Chenard, Jean-Pierre Bellocq, Stéphanie Delpous, Sébastien Molière, Anthony Sevrin, Karl Neuberger, Catherine Tomasetto, Carole Mathelin
发表日期
2016/11
期刊
Breast cancer research and treatment
卷号
160
页码范围
249-259
出版商
Springer US
简介
Purpose
We explored the clinical utility of human epidermal growth factor receptor-2 extracellular domain (HER2/ECD) in patients treated for an invasive breast cancer with HER2 overexpression.
Methods
We prospectively studied HER2/ECD levels in the sera of 334 women included between 2007 and 2014, all treated with trastuzumab. HER2/ECD levels were measured at diagnosis, during treatments, and along the follow-up. We investigated the relationship of HER2/ECD with other clinicopathological parameters at diagnosis, its prognosis value, and its utility during the monitoring of a neoadjuvant treatment and the follow-up.
Results
Elevated HER2/ECD at diagnosis correlated positively with parameters associated with tumor aggressiveness. Disease-free survival of non-metastatic patients was significantly shorter in …
学术搜索中的文章
N Reix, C Malina, MP Chenard, JP Bellocq, S Delpous… - Breast cancer research and treatment, 2016
