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Excessive foot pronation during gait is a risk factor in medial tibial stress syndrome (MTSS). Arch-support foot-orthoses are commonly used to manage overpronation, but it is unknown whether it is effective to manage MTSS. The present study investigated the effects of bilateral foot orthoses during running on dynamic foot-pressure distribution patterns in recreational runners with MTSS. Fifty novice (started within the last 4 months) runners diagnosed with MTSS (20.7 ± 2.2 years; 71.1 ± 8.6 kg; 1.78 ± 0.07 m; mean ± SD) and 50 anthropometrically-matched healthy novice runners (21.9 ± 2.4 years; 71.4 ± 8.8 kg; 1.73 ± 0.07 m) participated in this study. The dynamic foot-pressure distribution during running with and without bilateral arch-support foot-orthoses was measured using pedobarography. MTSS novice runners have more medially directed pressures during the touchdown phase of the …