作者
Adesoji O Ademuyiwa, Pollyanna Hardy, Emmy Runigamugabo, Pierre Sodonougbo, Hulrich Behanzin, Sosthène Kangni, Gérard Agboton, Luke Aniakwo Adagrah, Esther Adjei-Acquah, Ato Oppong Acquah, James Ankomah, Ralph Armah, Regina Acquah, Kwame Gyambibi Addo, Dorcas Otuo Acheampong, Nii Armah Adu-Aryee, Fatao Abubakari, Abraham Titigah, Frank Owusu, Raphael Adu-Brobbey, Vivian Adobea, Francis Atindaana Abantanga, Arun Gautham, Dimple Bhatti, Esther Daniel Mark Jesudason, Manisha Aggarwal, Philip Alexander, Amos Dasari, Rahul Alpheus, Hemanth Kumar, Subrat Raul, Wenceslao Ángeles Bueno, Reyes Cervantes Ortiz, Isaac Baltazar Gomez, Claudia Caballero Cerdan, Mariana Barreto Gallo, Rozana Reyes Gamez, Irani Durán Sánchez, Lawal Abdullahi, Opeoluwa Adesanya, Moruf Abdulsalam, Victoria Adeleye, Ochomma Egwuonwu, Akeem Adeleke, Francis Adebayo, Godwin Chiejina, Olukayode Abayomi, Lukman Abdur-Rahman, Jude Ede, Uba Ezinne, Salathiel Kanyarukiko, Moses Dusabe, Aime Dieudonne Hirwa, Georges Bucyibaruta, Mary Augusta Adams, Cheryl Birtles, Zain Ally, Abdus-sami Adewunmi, Jonathan Cook, Julia Brown, Adewale O Adisa, Lawani Ismail, Aneel Bhangu, Omar Omar, Joana FF Simoes, Elizabeth Li, Azmina Verjee, Pamphile Assouto, Djifid Morel Seto, Cyrile Kpangon, Rene Ahossi, Bin Baaba Alhaji Alhassan, Vera Agyekum, Leslie Issa Adam-Zakariah, Frank Assah-Adjei, Christopher Asare, James Amoako, Enoch Appiah Akosa, Jane Acquaye, Faisal Adjei, Cletus Ballu, Christian Larbi Coompson, Amos Bennin, Darling Ramatu Abdulai, Alice Hepzibah, William Bhatti, Priyadarshini K Paul, Parth Dhamija, Josy Thomas, Priya Jacob, Ashish Choudhrie, Nitin Peters, Rajeev Sharma, Francisco Barbosa Camacho, Gonzalo Hernandez Gonzalez, Celina Cuellar Aguirre, David Dominguez Solano, Ana Cortes Flores, Roque Lincona Menindez, Diana Gonzalez Vazquez, Khadija Ado, David Awonuga, Abimbola Adeniran, Adesoji Ademuyiwa, Okechukwu Ekwunife, Wilson Adenikinju, Oseremen Aisuodionoe-Shadrach, Ekpo Edet, Rukiyat Abdus-Salam, Nurudeen Adeleke, Sebastian Ekenze, Matthew Francis, Francine Mukaneza, Emelyne Izabiriza, Elysee Kabanda, Gisele Juru Bunogerane, Richard Crawford, Mathete Ivy, David Jayne, Simon Cousens, Sohini Chakrabortee, Dhruva Ghosh, Frank Enoch Gyamfi, Felicity Brant, Michel Fiogbe, Yannick Tandje, Marcelin Akpla, Raoul Baderha Ngabo, Mabel Pokuah Amoako-Boateng, Eric Agyemang, Esther Asabre, Anthony Appiah Boakye, Delali Akosua Gakpetor, Akosua Dwamena Appiah, Percy Boakye, Michael Adinku, Erica Akoto, Charles Gyamfi Barimah, Abdul-Hamid Labaran, Fred Dankwah, Daniel Kwesi Acquah, Grace Mary, Karan Bir, Latha Madankumar, Himani Gupta, Pradeep Zechariah, Elizabeth Kurien, Rakesh Vakil, Aldo Bernal Hernández, Rosa Hernandez Krauss
发表日期
2021/11/6
期刊
The Lancet
卷号
398
期号
10312
页码范围
1687-1699
出版商
Elsevier
简介
Background
Surgical site infection (SSI) is the most common postoperative complication worldwide. WHO guidelines to prevent SSI recommend alcoholic chlorhexidine skin preparation and fascial closure using triclosan-coated sutures, but called for assessment of both interventions in low-resource settings. This study aimed to test both interventions in low-income and middle-income countries.
Methods
FALCON was a 2 × 2 factorial, randomised controlled trial stratified by whether surgery was clean-contaminated, or contaminated or dirty, including patients undergoing abdominal surgery with a skin incision of 5 cm or greater. This trial was undertaken in 54 hospitals in seven countries (Benin, Ghana, India, Mexico, Nigeria, Rwanda, and South Africa). Patients were computer randomised 1:1:1:1 to: (1) 2% alcoholic chlorhexidine and non-coated suture, (2) 2% alcoholic chlorhexidine and triclosan-coated suture, (3 …
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AO Ademuyiwa, P Hardy, E Runigamugabo… - The Lancet, 2021