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This study evaluated the safety and effectiveness of an 8-week full-body resistance and aerobic exercise program for 27 survivors of breast cancer (age, 57.7+/-7.2 years; years posttreatment, 0.8-21.0) with prior upper-body conditioning. Physical fitness and quality-of-life (QOL) measures were obtained before and after the training period. Lymphedema, evaluated via arm volume measurement at baseline, was self-monitored throughout the trial. Sum of skinfolds, waist girth, and hip girth were significantly reduced posttraining (p< 0.01), although body weight did not change. Significant improvements (p< 0.01) were observed in upper-body strength (35.6+/-16.4%) and endurance (167.4+/-55.4%), lower-body strength (50.7+/-32.3%) and endurance (273.1+/-120.7%),[latin capital V with dot above] O2peak, trunk flexibility, and flexibility of the ipsilateral (surgical) and contralateral shoulder joint. Psychological QOL and …