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There have been few head‐to‐head clinical trials of pharmacotherapies for alcohol withdrawal (AW). We, therefore, aimed to evaluate the comparative performance of pharmacotherapies for AW.

Six databases were searched for randomized clinical trials through November 2021. Trials were included after a blinded review by two independent reviewers. Outcomes included incident seizures, delirium tremens, AW severity scores, adverse events, dropouts, dropouts from adverse events, length of hospital stay, use of additional medications, total benzodiazepine requirements, and death. Effect sizes were pooled using frequentist random‐effects network meta‐analysis models to generate summary ORs and Cohen's d standardized mean differences (SMDs).

Across the 149 trials, there were 10 692 participants (76% male, median 43.5 years old). AW severity spanned mild …