作者
Yuehui Zhang, Wei Zhao, Hongfei Xu, Min Hu, Xiaozhu Guo, Wenyan Jia, Guoqi Liu, Juan Li, Peng Cui, Susanne Lager, Amanda Nancy Sferruzzi‐Perri, Wei Li, Xiao‐ke Wu, Yanhua Han, Mats Brännström, Linus R Shao, Håkan Billig
发表日期
2019/8
期刊
The Journal of physiology
卷号
597
期号
15
页码范围
3927-3950
简介
Key points
- Women with polycystic ovary syndrome (PCOS) commonly suffer from miscarriage, but the underlying mechanisms remain unknown.
- Herein, pregnant rats chronically treated with 5α‐dihydrotestosterone (DHT) and insulin exhibited hyperandrogenism and insulin resistance, as well as increased fetal loss, and these features are strikingly similar to those observed in pregnant PCOS patients.
- Fetal loss in our DHT+insulin‐treated pregnant rats was associated with mitochondrial dysfunction, disturbed superoxide dismutase 1 and Keap1/Nrf2 antioxidant responses, over‐production of reactive oxygen species (ROS) and impaired formation of the placenta.
- Chronic treatment of pregnant rats with DHT or insulin alone indicated that DHT triggered many of the molecular pathways leading to placental abnormalities and fetal loss, whereas insulin often exerted distinct effects on placental gene expression …
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