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Dunaliella salina a green marine alga is known for its carotenoid accumulation, having various applications in the health and nutritional products. The purpose of present study was to evaluate the ability of D. salina algal powder extract to protect against oxidative stress In vivo using animal models. Treatment of albino Wistar strain rats with 125 μg /kg and 250 μg/kg b.w. showed significant protection when compared to toxin treated (CCl₄) group. Since β-carotene is major constituent of Dunaliella the results were also compared with group treated with 250 μg/kg b.w (p.o.) synthetic all trans β-carotene. Treatment of CCl₄ at dose of 2.0 g /kg b.w decreased the activities of various antioxidant enzymes like catalase, superoxide dismutase (SOD) and peroxidase by 45.9%, 56% and 54% respectively compared to control group and lipid peroxidation value increased nearly 2 folds. Pretreatment of rats with 125 μg …