作者
Kotamballi N Chidambara Murthy, Guddadarangavvanahally K Jayaprakasha, Bhimanagouda S Patil
发表日期
2012/8/5
期刊
European journal of pharmacology
卷号
688
期号
1-3
页码范围
14-21
出版商
Elsevier
简介
In the current paper, berberine, an isoquinoline alkaloid, was tested for its chemopreventive potential in colon cancer (SW480) cells. Berberine inhibited proliferation of colon cancer cells in a dose‐ and time‐dependent manner. Interestingly, this compound exhibited minimum toxicity in normal cells at 200μM. Berberine arrested SW480 cell cycle at G2/M phase, which was supported by induction of p21 expression. Induction of a series of biochemical events, including loss of mitochondrial membrane potential, release of cytochrome-c to cytosol, induction of Bcl-2 family proteins, caspases and cleavage of poly (ADP-ribose) polymerase (PARP), by berberine suggests its ability to induce apoptosis. In addition, berberine also inhibited inflammation, as evidenced by induction of expression of NFκB and Cox2. Furthermore, berberine inhibited caspase-8 mediated angiogenesis, as confirmed through expression of tumor …
学术搜索中的文章
KNC Murthy, GK Jayaprakasha, BS Patil - European journal of pharmacology, 2012