作者
Rohit Bhatia, Sankha S Chakrabarti, Upinder Kaur, Gaurav Parashar, Anindita Banerjee, Ravindra K Rawal
发表日期
2021/9/1
来源
Current Alzheimer Research
卷号
18
期号
10
页码范围
802-830
出版商
Bentham Science Publishers
简介
Alzheimer’s disease (AZD) is an age-associated neurodegenerative disorder and is one of the common health issues around the globe. It is characterized by memory loss and a decline in other cognitive domains, including executive function. The progression of AZD is associated with complex events, and the exact pathogenesis is still unrevealed. Various mechanisms which are thought to be associated with the initiation of AZD include a decreased concentration of acetylcholine (ACh), deposition of amyloid-β (Aβ) peptide, dyshomeostasis of redox metal ions, and prolonged oxidative stress. Due to the simultaneous progression of diverse pathogenetic pathways, no ideal therapeutic agent has been developed to date. The drugs which are available against AZD provide only symptomatic benefits and do not have disease-modifying activity. Therefore, in search of ideal therapeutic candidates, the concept of …
引用总数
学术搜索中的文章