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Recent publications present an opportunity to reflect on the importance of sharing negative results and the opportunity this presents for growth as a scientist and as a scientific mentor. We share these perspectives, acknowledging that they may not be generalizable to other research teams. From the mentor’s point of view: Every time I arrive at the end of an experiment or a clinical trial, I hold my breath as I await the analysis of results that may have taken years to acquire—the stakes are so high, that I often ask for three independent analyses. Sometimes, I experience a surreal moment of relief and elation because my hypothesis turned out to be correct—and I made a difference in the way I intended. Sometimes though, my hypothesis is just incorrect. I am not as upset by this as one might think—it just means a different hypothesis will be correct. I know the safety measures are sound, so the Institutional Review Board …