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Objective : To measure the change in cardiovascular risk factors achievable in families over one year by a cardiovascular screening and lifestyle intervention in general practice.

Design : Randomised controlled trial in 26 general practices in 13 towns in Britain.

Subjects : 12472 men aged 40-59 and their partners (7460 men and 5012 women) identified by household.

Intervention : Nurse led programme using a family centred approach with follow up according to degree of risk.

Main outcome measures : After one year the pairs of practices were compared for differences in (a) total coronary (Dundee) risk score and (b) cigarette smoking, weight, blood pressure, and random blood cholesterol and glucose concentrations.

Results : In men the overall reduction in coronary risk score was 16% (95% confidence interval 11% to 21%) in the intervention practices at one year. This was partitioned between systolic pressure (7 …